At work I now use the Clojure setup that everyone else uses, emacs+swank-clojure, with our custom repositories. For my own Clojure hacking (my own projects) I have just about settled on using cljr for convenience and agility. For me, the big win is being able to access Clojure libraries, Java libraries, and JAR files containing data sets I use often for NLP work from any directory. I don't need a heavy weight project, like for example, using Leiningen with all dependencies locally loaded. cljr uses Leiningen to manage the packages in the single ~/.cljr repository. When you startup cljr, everything in ~/.cljr is on your JVM classpath: this may seem a little heavy, but it is very convenient. As an example, this morning I noticed an old Twitter direct message from the author of Nozzle library asking me if I had a chance to try it. Instead of setting up a separate Leiningen project directory, I just did a cljr install com.ashafa/nozzle 0.2.1 , went to my catch-all directory where I k